Nature’s spark plug: coenzyme Q10 and ubiquinol

Coenzyme Q10 (CoQ10) is a naturally occurring antioxidant found in every cell of the body, essential for energy production and overall cellular health. It plays a pivotal role in the production of adenosine triphosphate (ATP), the energy currency of the cell, which powers various biological processes, hence the name ‘nature’s spark plug’.

However, when looking at CoQ10 supplements, you’ll often find two forms: ubiquinone(CoQ10) and ubiquinol. Understanding the difference and benefits between these two forms can help you make the best choice for your health needs.

What is coenzyme Q10 (ubiquinone)?

Ubiquinone is the oxidised form of CoQ10, which the body needs to convert into ubiquinol to carry out its biological functions. Ubiquinone is often referred to as the ‘non-activated’ form of CoQ10. It has been used in supplements for decades and is known for supporting cardiovascular health, reducing LDL cholesterol, boosting energy levels and acting as an antioxidant to combat free radicals.

When taken as a supplement, ubiquinone must be converted by the body into ubiquinol before it can be used effectively. This conversion process happens naturally in healthy individuals but may become less efficient with age or in people with certain health conditions such as cardiovascular disease, diabetes, infertility and chronic fatigue states. 

So, what is ubiquinol?

Ubiquinol is the reduced, or active antioxidant form of CoQ10. It is the form that your body actually uses to produce energy and fight oxidative stress. Research shows that ubiquinol is more bioavailable than ubiquinone, meaning it is more easily absorbed and utilised by the body[i].

 Since it doesn’t need to be converted, ubiquinol is particularly beneficial for individuals over 40 or those with conditions that impair the body's ability to convert ubiquinone into ubiquinol. It is also a stronger antioxidant, providing enhanced protection against cellular damage.

Key differences between CoQ10 and ubiquinol

1. Chemical form

• CoQ10 (Ubiquinone): The oxidised form that needs to be converted into ubiquinol for the body to use

• Ubiquinol: The reduced, active form that the body can use directly

2. Absorption

• CoQ10: Generally less bioavailable and requires conversion to ubiquinol, which can be less efficient in older adults or those with pre-existing health conditions

• Ubiquinol: More readily absorbed, providing faster and more effective benefits, especially in individuals with compromised health

3. Antioxidant Power

• CoQ10: Provides antioxidant benefits after being converted to ubiquinol

• Ubiquinol: Offers stronger and immediate antioxidant protection

4. Benefits of supplementing with CoQ10 and ubiquinol

Both forms offer significant health benefits, particularly for heart health, brain function and energy metabolism. They have been shown to support:

• Cardiovascular health (maintaining healthy LDL cholesterol levels, heart health, blood pressure and statin medication support)

• Energy production in the body

• Migraine prevention

• Exercise performance, endurance and recovery

• Healthy ageing

• Cognitive and mental function during ageing

• Fertility for men and women (being incorporated into some IVF treatment plans)

 However, ubiquinol may offer distinct advantages for older adults or individuals with chronic conditions due to its superior absorption and immediate antioxidant effects. For younger, healthy individuals, ubiquinone can still provide meaningful benefits at a lower cost, especially if their body efficiently converts it. Ultimately, both forms support cellular energy production and provide powerful antioxidant protection, making them valuable additions to health and wellbeing.   

Ready to take control of your health?

Understanding the right CoQ10 supplement for your unique needs can make all the difference in your energy, heart health and overall wellbeing. Not sure whether CoQ10 or ubiquinol is best for you? Get expert guidance and a personalised treatment plan by booking a consultation. Take the next step toward feeling your best naturally now. 

References

[1] Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2014;3(1):13-17.